Endocrine Abstracts

Childhood obesity is increasing in prevalence and is associated with insulin resistance and Type II diabetes in later life. Site-specific differences in adipose tissue accumulation and associated insulin sensitivity may contribute to these problems.The aims of our study were: 1. To isolate and characterise, subcutaneous (SC) and visceral (V) preadipocytes using small biopsies from pre-pubertal children (ages:4-8years(n=3)) undergoing elective abdominal surgery, with normal...

Obesity is associated with the development of the metabolic syndrome, and the current epidemic of childhood obesity raises enormous concerns regarding future pandemics of diabetes and cardiovascular disease.We report preliminary data from 26 obese caucasian children (age 3.8-17.8yrs; 16 prepubertal/10 adolescents; mean Body Mass Index Standard Deviation Score (BMI SDS) +3.85 - range 2.61-6.66) who attend our paediatric obesity clinic. BMI SDS was calculated using British 1...

An eight-year-old girl developed Insulin Dependent Diabetes Mellitus. Two years previously, she had been referred to the Department of Endocrinology with concerns regarding short stature, but had not attended. She was mildly dysmorphic and her height and weight both plotted to below the 0.4th centile for age (Height Standard Deviation Score = -3.75, Weight Standard Deviation Score = -2.28). Her mother was also noted to be short at 147.2cm. There was no family history of deafne...